Saturday, December 02, 2006

Propolis Component May Prevent Colon Cancer

Administration of Artepillin C May Prevent Colon Cancer
Medical Patent Week, 12/10/2006

According to a study from Japan, "Potential chemopreventive agents exist in foods.

Artepillin C in Brazilian propolis was investigated for its effects on colon carcinogenesis."

"We had found that artepillin C was a bioavailable antioxidant, which could be incorporated into intestinal Caco-2 and hepatic HepG2 cells without any conjugation and inhibited the oxidation of intracellular DNA. Artepillin C was then added to human colon cancer WiDr cells. It dose-dependently inhibited cell growth, inducing G(0)/G(1) arrest…

The researchers concluded, "Artepillin C appears to prevent colon cancer through the induction of cell-cycle arrest by stimulating the expression of Cip1/p21 and to be a useful chemopreventing factor in colon carcinogenesis."

Shimizu and colleagues published the results of their research in Molecular Carcinogenesis (Artepillin C in Brazilian propolis induces G(0)/G(1) arrest via stimulation of Cip1/p21 expression in human colon cancer cells. Mol Carcinog, 2005;44(4):293-299).

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